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Scientists in Massachusetts report using cells from cloned cow
embryos to grow kidney-like organs that function and are not rejected
when implanted into adult cows.
The research, described in an interview with The Washington Post
by Robert P. Lanza, chief scientist on the project at Advanced
Cell Technology in Worcester, MA, would mark the first use of
cloning technology to grow genetically matched organs for transplantation.
If the approach can ultimately be used to make human kidneys
from cloned human embryos, it could help address the human organ
shortage that has more than 50,000 Americans currently waiting
for a cadaver kidney to become available for a kidney transplant.
While it is not known whether the organs created cow embryons
can perform all of the functions of a cow kidney, Lanza said "we
can say clearly that these kidneys produced urine and survived
for several months inside the cows."
Lanza said he was reluctant to reveal details of the work because
the team hopes to publish the new results in peer-reviewed journals,
which tend not to publish results that have been publicly released.
But he said the team
took a single skin cell from an adult cow's ear and fused it with
a cow's egg whose own genetic material had been removed, creating
a cow embryo that they grew to an early fetal stage at which they
identified immature cells starting to turn into kidney cells.
Working with
Anthony Atala at Children's Hospital in Boston, he said they seeded
some of those immature renal cells onto a sponge-like, two-inch-long
biocompatible scaffolding. The mass ultimately came to resemble
a miniature kidney.
Lanza said
several of the mini-organs were then implanted under the skin
of the cow that donated the ear cell. The organs obtained nutrients
from surrounding blood vessels, and the kidneys produced urine,
which drained into small synthetic bags, or bladders.
Other
sources: Washington Post, Advanced Cell Technology
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