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Saudi Arabian doctors reported performing the world's first uterus
transplant, from a 46-year-old woman to a 26-year-old who had
a hysterectomy because
of a hemorrhage after childbirth, but who was still hoping to
have another baby.
The transplanted uterus
remained healthy for 99 days, and ultrasound tests showed the
uterus responding with a monthly buildup of endometrial tissue,
doctors reported. The woman had two normal menstrual periods.
All went well until
the 99th day, the doctors said, when the recipient reported pelvic
discomfort, and tests showed that blood flow to the uterus had
stopped. A hysterectomy was performed.
The doctors
reported that the problem may have occurred because the uterus
was not anchored securely enough, leading to "probable tension,
torsion, or kinking" of blood vessels.
The idea of
uterus transplants was first explored in the 1950s. But after
20 years of failed experiments on dogs and baboons, many scientists
considered it technically too challenging.
A uterine
transplant differs from most organ transplants in that the uterus
is fed by small blood vessels, each of which must be reattached
with microsurgical techniques.
The Saudi
transplant, performed in April 2000, was described in the International
Journal of Gynecology and Obstetrics by Dr. Wafa Fageeh, Dr. Hassan
Raffa, Dr. Hussain Jabbad and Dr. Anass Marzouki, of the King
Fahd Hospital and research center in Jidda, Saudi Arabia.
Fageeh said
she and her colleagues had practiced on 16 baboons and two goats,
perfecting vessel attachment techniques before performing the
transplant on the woman.
The recipient
took anti-rejection drugs before and after the surgery, as well
as hormones to help the uterus develop a normal lining, the doctors
said.
Other
sources: International Journal of Gynecology and Obstetrics
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