News From Transplant Week of March 17, 2002 / Vol. 3 No. 11

 

CDC: Transplant Patient Died From Parasite in New Organs

 

Three transplant patients contracted a dangerous parasitic disease from their new organs, and one of the three died of the disease, according to the U.S. Centers for Disease Control and Prevention.

The transplants are linked to Emory University, though whether the organs were retrieved there or the transplants took place there has not been disclosed. Emory representatives would say only that they were aware of the cases.

A 37-year-old who received a kidney-pancreas transplant died of Chagas disease in October; a 32-year-old who received a liver transplant died of transplant complications in July; and a 69-year-old who received the other kidney was treated for four months and is recovering. Names and hometowns were not disclosed.

The infected organs all came from the cadaver of a Central American immigrant who was apparently infected with T. cruzi, a parasite which causes Chagas disease, the CDC said.

The disease, previously confined to Latin America, can cause heart irregularities. Ten percent to 30 percent of people infected with the parasite develop full-blown Chagas disease.

More than 16 million people are reported to be infected by the parasite in Central and South America, and CDC officials estimated as many as 100,000 Latin American immigrants in the United States may carry the parasite. Since the disease can lie dormant in the body for many years, neither the Central American donor nor the donor's family may have known of the infection.

The women are the first known cases of Chagas being transmitted by transplant in the United States, said Dr. Barbara Herwaldt of the CDC. The CDC said it was consulting with transplant organizations nationwide to decide whether to start screening for T. cruzi.

"It's a complex issue," said Herwaldt. "Which donors would be screened? What test would be used? Right now even blood donors aren't screened for this infection."

"We screen for a large number of potentially transmissible illnesses -- for HIV, hepatitis and a whole host of other things," said Dr. Christian P. Larsen, director of the Emory Transplant Center. "The problem is that there are a whole host of diseases around the world that are potentially transmissible, and it is exceedingly difficult given the time constraints of organ donation to be able to screen for every conceivable illness."

Other sources: CDC, Atlanta Journal and Constitution