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Scientists in the United
Kingdom report they have made kidney tissue out of bone marrow
cells, a breakthrough that may lead to new treatments for kidney
damage or ultimately even allow scientists to regenerate new kidneys.
Researchers say the
development may one day provide an alternative for the tens of
thousands of patients awaiting kidney transplant surgery, enabling
them to repair damaged kidneys rather than replacing them with
donated organs.
"This discovery
is very exciting and means we have new ways to treat kidney damage
caused by cancer or other diseases," said Professor Nicholas
Wright, head of the Imperial Cancer Research Fund's histopathology
unit and one of the scientists involved in the research.
Reporting in the Journal
of Pathology, Wright said scientists analyzed female kidneys placed
into male patients who had undergone bone marrow transplants.
Using a special DNA probe that identifies male cells, they found
male kidney cells that had originated in the bone marrow in the
donated female kidneys.
Wright's team earlier
had determined that bone marrow cells could turn into liver cells.
"Doctors could
use stem cells from the patient's own bone marrow to replenish
kidney cells lost by injury," Wright said. "This would
be of huge benefit as the kidney is very poor at repairing itself.
Furthermore, there would be much less complication with the kidneys
rejecting the new cells, because they would come from the patient's
own body."
Sir Paul Nurse,
director general of the Imperial Cancer Research Fund, said that
"ultimately, this research may one day lead to regenerating
a new kidney using the patient's own stem cells.
"This
would solve the desperate shortage of available kidney transplants
and avoid problems with rejection. The potential for therapies
is enormous and very exciting," Nurse said.
Other
Sources: Journal of Pathology, The Guardian, Press Association
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